KMT2E-AS1

Across TCGA pan-cancer cohorts, KMT2E-AS1 RNA is linked to patient survival in 25 of 34 cancer types, making it the most broadly survival-associated KMT2E-AS1 data layer.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher KMT2E-AS1 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated KMT2E-AS1 expression acts as an unfavorable survival marker, although some lineages such as CESC and BLCA show a favorable association.

KIRC, ACC, and COAD are the cancer types where KMT2E-AS1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	DFS	Median	All	0.549	0.691	<.001	83	view →
ACC	OS	Median	All	0.780	0.959	<.001	79	view →
COAD	DFS	Quartile	All	0.376	0.595	<.001	75	view →
LGG	DFS	Median	All	0.650	0.807	<.001	39	view →
UVM	DFS	Tertile	III,IV	0.288	0.925	.001	32	view →
CESC	OS	Quartile	All	0.875	0.691	.005	28	view →
BLCA	OS	Quartile	All	0.766	0.616	.004	27	view →
UCS	OS	Quartile	II,III,IV	0.698	0.279	.019	22	view →
PAAD	OS	Quartile	All	0.557	0.227	.002	18	view →
HNSC	OS	Tertile	II,III,IV	0.802	0.679	.012	18	view →
THYM	OS	Median	II,III,IV	0.954	0.724	.010	15	view →
LUAD	OS	Quartile	II,III,IV	0.826	0.670	.008	13	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 25 lineages.

KMT2E-AS1–KIRC (DFS)

Open the KIRC breakdown →