KMT2E-AS1

Across TCGA pan-cancer cohorts, KMT2E-AS1 RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of KMT2E-AS1’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where KMT2E-AS1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types KMT2E-AS1 is over-expressed in tumor, although a few such as KICH and THCA show the opposite, repressed pattern.

COAD, BLCA, and LIHC are the cancer types where KMT2E-AS1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in KMT2E-AS1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Female	II,III,IV	+0.704	<.001	9	view →
BLCA	All	All	+0.688	.001	8	view →
LIHC	Male	All	+1.009	<.001	7	view →
KIRC	All	IV	+0.573	.010	6	view →
KICH	All	All	−1.194	<.001	5	view →
CHOL	All	All	+1.261	<.001	3	view →
ESCA	All	All	+0.846	.002	3	view →
HNSC	Male	III,IV	+0.846	.004	3	view →
THCA	All	All	−0.381	.002	3	view →
PRAD	All	All	+0.325	.012	2	view →
STAD	All	All	+0.336	.040	1	view →
BRCA	Female	II,III,IV	−0.204	.034	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

KMT2E-AS1–COAD

Open the COAD breakdown →