KMT2D

Across TCGA cell cohorts, KMT2D mutation is significantly associated with the RNA expression of many other genes, with 2,466 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible KMT2D-associated genes across cancer lineages are MTFMT, RREB1, and HSPD1. Each is linked with KMT2D in more than 3 cancer types. Because this analysis shows association rather than direction, both KMT2D-to-partner and partner-to-KMT2D results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MTFMT grouped by KMT2D-low versus KMT2D-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KMT2D→partner) and Y-score (partner→KMT2D) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	MTFMT →	+0.483	+1.807	<.001	.001	3	4
LARGE_INTESTINE	RREB1 →	+0.469	+1.265	.004	.003	3	4
LARGE_INTESTINE	HSPD1 →	+0.432	+1.588	.002	<.001	3	4
LARGE_INTESTINE	DHRS13 →	+0.823	+2.415	<.001	<.001	3	4
LARGE_INTESTINE	SPATA5L1 →	+0.309	+1.275	.008	.009	3	4
BLOOD_Leukemia	KLHL11 →	+0.614	+1.896	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,466 associations by consensus.

MTFMT by KMT2D expression — LARGE_INTESTINE

Explore this box plot interactively →