KMT2C

Across TCGA pan-cancer cohorts, KMT2C mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated KMT2C data layer compared with 26 for mass-spec protein and 9 for mutation status.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher KMT2C mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated KMT2C expression acts as an unfavorable survival marker, although some lineages such as UCEC and LSCC show a favorable association.

UCEC, LSCC, and LUAD are the cancer types where KMT2C mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	DFS	Median	All	0.946	0.770	.004	28	view →
LSCC	DFS	Median	II,III,IV	0.873	0.518	.003	27	view →
LUAD	OS	Tertile	II,III,IV	1.000	0.799	.007	11	view →
HNSC	DFS	Median	All	0.698	1.000	.020	10	view →
CCRCC	OS	Median	II,III,IV	0.454	1.000	.014	6	view →
PDAC	DFS	Tertile	IV	0.777	0.217	.024	3	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

KMT2C–UCEC (DFS)

Open the UCEC breakdown →