KMT2B

Across TCGA patient cohorts, KMT2B RNA expression is significantly associated with the protein abundance of many other proteins, with 10,451 significant associations in total. GBM shows the largest number of these associations.

The most reproducible KMT2B-associated proteins across cancer lineages are UBA2, POLR2E, and KMT2B_S351. Each is linked with KMT2B in more than 4 cancer types. Because this analysis shows association rather than direction, both KMT2B-to-partner and partner-to-KMT2B results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, KMT2B versus UBA2 in PDAC, with a Pearson correlation of 0.46.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (KMT2B→partner) and Y-score (partner→KMT2B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	UBA2 →	+0.252	+0.503	<.001	<.001	3	5
GBM	POLR2E →	+0.233	+0.533	.001	<.001	3	5
LSCC	KMT2B_S351 →	+0.513	+0.574	<.001	.001	3	5
PDAC	KMT2B_T2083 →	+0.624	+0.531	.007	.006	3	5
GBM	LSM14A_S216 →	+0.369	+0.610	<.001	<.001	3	5
GBM	WDR5 →	+0.320	+0.463	<.001	.005	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 10,451 associations by consensus.

KMT2B vs UBA2 — PDAC

Explore this scatter interactively →