KMT2B

Across TCGA pan-cancer cohorts, KMT2B RNA is linked to patient survival in 27 of 34 cancer types, making it the most broadly survival-associated KMT2B data layer compared with 11 for mutation status and 4 for mass-spec protein.

The strongest signal is observed in uterine carcinosarcoma (UCS), where higher KMT2B RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated KMT2B expression acts as an unfavorable survival marker, although some lineages such as UCS and HNSC show a favorable association.

UCS, ACC, and HNSC are the cancer types where KMT2B RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCS	DFS	Median	II,III,IV	0.559	0.129	<.001	82	view →
ACC	DFS	Median	All	0.371	0.788	<.001	82	view →
HNSC	DFS	Quartile	IV	0.502	0.237	<.001	70	view →
CESC	DFS	Tertile	All	0.753	0.906	<.001	66	view →
LGG	DFS	Median	All	0.308	0.488	<.001	48	view →
LIHC	DFS	Tertile	All	0.442	0.607	<.001	47	view →
KIRC	DFS	Quartile	II,III,IV	0.331	0.608	<.001	38	view →
THYM	OS	Median	All	1.000	0.750	.002	35	view →
OV	OS	Tertile	III,IV	0.308	0.426	.007	34	view →
MESO	OS	Tertile	III,IV	0.420	0.655	.014	30	view →
SCLC	OS	Median	II,III,IV	1.000	0.462	.005	15	view →
THCA	OS	Median	All	0.964	1.000	.016	14	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 27 lineages.

KMT2B–UCS (DFS)

Open the UCS breakdown →