KMT2B

Across TCGA patient cohorts, KMT2B protein abundance is significantly associated with the RNA expression of many other genes, with 7,994 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible KMT2B-associated genes across cancer lineages are OVOL3, UBA2, and ZNF507. Each is linked with KMT2B in more than 4 cancer types. Because this analysis shows association rather than direction, both KMT2B-to-partner and partner-to-KMT2B results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, KMT2B versus OVOL3 in LSCC, with a Pearson correlation of 0.45.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KMT2B→partner) and Y-score (partner→KMT2B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	OVOL3 →	+0.652	+0.264	<.001	<.001	3	5
HNSC	UBA2 →	+0.788	+0.299	.001	.003	3	5
HNSC	ZNF507 →	+0.628	+0.238	<.001	<.001	3	5
HNSC	ZNF567 →	+0.775	+0.267	<.001	<.001	3	5
BRCA	LSM14A →	+0.524	+0.425	.001	<.001	3	5
HNSC	PDCD5 →	+0.639	+0.209	<.001	.007	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 7,994 associations by consensus.

KMT2B vs OVOL3 — LSCC

Explore this scatter interactively →