KMT2B

Across TCGA patient cohorts, KMT2B mutation is significantly associated with the RNA expression of many other genes, with 8,533 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible KMT2B-associated genes across cancer lineages are GPR173, SAYSD1, and ZFYVE19. Each is linked with KMT2B in more than 4 cancer types. Because this analysis shows association rather than direction, both KMT2B-to-partner and partner-to-KMT2B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GPR173 grouped by KMT2B-low versus KMT2B-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KMT2B→partner) and Y-score (partner→KMT2B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	GPR173 →	-0.619	-1.234	<.001	<.001	3	5
BLCA	SAYSD1 →	-0.461	-3.678	.002	.001	3	5
SKCM	ZFYVE19 →	+0.324	+1.530	<.001	.001	3	5
UCEC	NUP188 →	+0.406	+1.169	<.001	<.001	3	5
SKCM	ZNF660 →	-0.524	-3.157	<.001	<.001	3	5
SKCM	GSTO1 →	+0.543	+1.652	<.001	.005	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 8,533 associations by consensus.

GPR173 by KMT2B expression — UCEC

Explore this box plot interactively →