KMT2B

Across TCGA patient cohorts, KMT2B mutation is significantly associated with the total protein of many other genes, with 97 significant associations in total. COAD shows the largest number of these associations.

The most reproducible KMT2B-associated genes across cancer lineages are GAPDH, INPP4B, and ATM. Each is linked with KMT2B in more than 3 cancer types. Because this analysis shows association rather than direction, both KMT2B-to-partner and partner-to-KMT2B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GAPDH grouped by KMT2B-low versus KMT2B-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KMT2B→partner) and Y-score (partner→KMT2B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	GAPDH →	+0.574	+3.700	<.001	.001	3	4
COAD	INPP4B →	-0.353	-1.213	.001	.033	3	4
COAD	ATM →	-0.572	-2.584	<.001	<.001	3	4
COAD	Caveolin-1 →	-0.423	-1.584	.043	.032	3	4
COAD	c-Kit →	-0.584	-1.678	<.001	.018	3	3
COAD	p27_pT157 →	+0.088	+1.724	.040	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 97 associations by consensus.

GAPDH by KMT2B expression — COAD

Explore this box plot interactively →