KMT2B

Across TCGA cell cohorts, KMT2B RNA expression is significantly associated with the go_rna of many other GO terms, with 4,103 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible KMT2B-associated GO terms across cancer lineages are Regulation of DNA repair, Negative regulation of gene expression, epigenetic, and Epigenetic regulation of gene expression. Each is linked with KMT2B in more than 18 cancer types. Because this analysis shows association rather than direction, both KMT2B-to-partner and partner-to-KMT2B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of DNA repair grouped by KMT2B-low versus KMT2B-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (KMT2B→partner) and Y-score (partner→KMT2B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Regulation of DNA repair →	+0.064	+0.738	<.001	<.001	3	19
BONE	Negative regulation of gene expression, epigenetic →	+0.075	+0.847	<.001	<.001	3	18
BONE	Epigenetic regulation of gene expression →	+0.071	+0.795	<.001	<.001	3	18
PANCREAS	Regulation of DNA-templated transcription initiation →	+0.072	+0.909	<.001	<.001	3	18
STOMACH	Positive regulation of DNA recombination →	+0.076	+0.900	<.001	<.001	3	17
BONE	Heterochromatin organization →	+0.069	+0.847	<.001	<.001	3	17

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,103 associations by consensus.

Regulation of DNA repair by KMT2B expression — BONE

Explore this box plot interactively →