KMT2B

Across TCGA cell cohorts, KMT2B mutation is significantly associated with the RNA expression of many other genes, with 2,627 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible KMT2B-associated genes across cancer lineages are EXOSC9, PAICS, and SEMA3G. Each is linked with KMT2B in more than 3 cancer types. Because this analysis shows association rather than direction, both KMT2B-to-partner and partner-to-KMT2B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EXOSC9 grouped by KMT2B-low versus KMT2B-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KMT2B→partner) and Y-score (partner→KMT2B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	EXOSC9 →	+0.690	+3.459	<.001	<.001	3	4
LARGE_INTESTINE	PAICS →	+0.655	+2.216	<.001	<.001	3	4
LARGE_INTESTINE	SEMA3G →	+0.891	+2.628	<.001	<.001	3	4
LARGE_INTESTINE	POLR3G →	+1.239	+2.130	<.001	<.001	3	4
LARGE_INTESTINE	ASPHD2 →	+0.670	+1.721	<.001	.003	3	4
LARGE_INTESTINE	PAQR3 →	+0.795	+2.130	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,627 associations by consensus.

EXOSC9 by KMT2B expression — LARGE_INTESTINE

Explore this box plot interactively →