KMT2B

Across TCGA cell cohorts, KMT2B mutation is significantly associated with the mutation status of many other genes, with 6,731 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible KMT2B-associated genes across cancer lineages are PRRC2B, ABCC8, and KMT2D. Each is linked with KMT2B in more than 7 cancer types. Because this analysis shows association rather than direction, both KMT2B-to-partner and partner-to-KMT2B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PRRC2B grouped by KMT2B-low versus KMT2B-high in STOMACH.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KMT2B→partner) and Y-score (partner→KMT2B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	PRRC2B →	+3.949	+2.437	.001	.001	1	8
OVARY	ABCC8 →	+3.196	+2.345	.007	.007	1	8
LARGE_INTESTINE	KMT2D →	+1.847	+3.066	<.001	<.001	1	7
SKIN	GLI3 →	+3.275	+2.347	<.001	<.001	1	7
STOMACH	PLXNA1 →	+3.949	+2.437	.001	.001	1	7
STOMACH	BIRC6 →	+2.435	+2.435	.001	.001	1	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,731 associations by consensus.

PRRC2B by KMT2B expression — STOMACH

Explore this box plot interactively →