KMT2A

Across TCGA patient cohorts, KMT2A mutation is significantly associated with the RNA expression of many other genes, with 7,794 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible KMT2A-associated genes across cancer lineages are UQCR10, ADAM33, and LRRC43. Each is linked with KMT2A in more than 5 cancer types. Because this analysis shows association rather than direction, both KMT2A-to-partner and partner-to-KMT2A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, UQCR10 grouped by KMT2A-low versus KMT2A-high in STAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KMT2A→partner) and Y-score (partner→KMT2A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STAD	UQCR10 →	+0.369	+2.601	.003	<.001	3	6
UCEC	ADAM33 →	-0.715	-1.295	<.001	<.001	3	6
SKCM	LRRC43 →	-0.305	-1.090	.003	.005	3	6
COAD	SERP2 →	-0.923	-2.032	<.001	<.001	3	5
LUAD	PNMA8B →	-0.472	-3.549	.004	.002	3	5
COAD	TRIM16 →	+0.479	+2.415	<.001	.002	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 7,794 associations by consensus.

UQCR10 by KMT2A expression — STAD

Explore this box plot interactively →