KMT2A

Across TCGA cell cohorts, KMT2A RNA expression is significantly associated with the go_rna of many other GO terms, with 4,660 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible KMT2A-associated GO terms across cancer lineages are Termination of RNA polymerase II transcription, Positive regulation of double-strand break repair, and Meiotic chromosome condensation. Each is linked with KMT2A in more than 16 cancer types. Because this analysis shows association rather than direction, both KMT2A-to-partner and partner-to-KMT2A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Termination of RNA polymerase II transcription grouped by KMT2A-low versus KMT2A-high in PANCREAS.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (KMT2A→partner) and Y-score (partner→KMT2A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	Termination of RNA polymerase II transcription →	+0.118	+0.762	<.001	<.001	3	17
UPPER_AERODIGESTIVE_TRACT	Positive regulation of double-strand break repair →	+0.063	+1.060	<.001	<.001	3	17
BONE	Meiotic chromosome condensation →	+0.233	+1.698	<.001	<.001	3	16
LUNG_SCLC	Regulation of chromatin organization →	+0.105	+0.723	.002	<.001	3	16
STOMACH	Heterochromatin formation →	+0.076	+0.717	<.001	<.001	3	16
OVARY	Stress granule assembly →	+0.110	+0.800	<.001	<.001	3	16

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,660 associations by consensus.

Termination of RNA polymerase II transcription by KMT2A expression — PANCREAS

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