KMO

Across TCGA patient cohorts, KMO mutation is significantly associated with the RNA expression of many other genes, with 3,079 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible KMO-associated genes across cancer lineages are REEP4, PKM, and PKMP5. Each is linked with KMO in more than 2 cancer types. Because this analysis shows association rather than direction, both KMO-to-partner and partner-to-KMO results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, REEP4 grouped by KMO-low versus KMO-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KMO→partner) and Y-score (partner→KMO) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	REEP4 →	+0.391	+1.917	.001	<.001	3	3
UCEC	PKM →	+0.450	+2.415	<.001	<.001	3	3
UCEC	PKMP5 →	+0.243	+2.362	.006	<.001	3	3
LGG	RNU6-1274P →	+0.451	+6.491	<.001	.001	3	2
READ	MIR4774 →	+0.498	+4.672	<.001	.004	3	2
READ	MIR4797 →	+0.640	+4.054	<.001	.004	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,079 associations by consensus.

REEP4 by KMO expression — UCEC

Explore this box plot interactively →