KMO

Across TCGA pan-cancer cohorts, KMO RNA is linked to patient survival in 26 of 34 cancer types, making it the most broadly survival-associated KMO data layer compared with 5 for mutation status and 3 for mass-spec protein.

The strongest signal is observed in skin cutaneous melanoma (SKCM), where higher KMO RNA is associated with better overall survival. In most high-consensus cancer types, elevated KMO expression acts as an unfavorable survival marker, although some lineages such as SKCM and UCS show a favorable association.

SKCM, UVM, and LGG are the cancer types where KMO RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
SKCM	OS	Median	All	0.412	0.266	<.001	90	view →
UVM	OS	Median	All	0.417	0.760	<.001	75	view →
LGG	OS	Median	All	0.727	0.888	<.001	53	view →
LAML	DFS	Tertile	All	0.370	0.739	.001	30	view →
ACC	OS	Quartile	III,IV	0.311	0.811	.023	25	view →
UCS	DFS	Tertile	IV	0.814	0.250	.024	24	view →
CESC	DFS	Quartile	II,III,IV	0.895	0.616	.007	24	view →
GBM	OS	Quartile	All	0.236	0.372	.010	20	view →
KIRC	DFS	Quartile	All	0.726	0.855	.011	18	view →
BRCA	OS	Median	All	0.896	0.950	.001	18	view →
THYM	DFS	Median	All	0.782	0.968	.009	17	view →
STAD	DFS	Quartile	All	0.452	0.728	.002	11	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 26 lineages.

KMO–SKCM (OS)

Open the SKCM breakdown →