KMO

Across TCGA patient cohorts, KMO mutation is significantly associated with the total protein of many other genes, with 33 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible KMO-associated genes across cancer lineages are FASN, ASNS, and 4E-BP1. Each is linked with KMO in more than 1 cancer types. Because this analysis shows association rather than direction, both KMO-to-partner and partner-to-KMO results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FASN grouped by KMO-low versus KMO-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KMO→partner) and Y-score (partner→KMO) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	FASN →	+0.460	+2.815	.032	.036	3	2
COAD	ASNS →	+0.749	+2.815	<.001	.036	3	2
UCEC	4E-BP1 →	+0.299	+1.614	<.001	.010	3	2
UCEC	eIF4E →	+0.145	+1.415	.026	.010	3	2
UCEC	MEK1 →	+0.397	+2.807	<.001	<.001	3	2
UCEC	Annexin-1 →	+0.628	+1.893	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 33 associations by consensus.

FASN by KMO expression — COAD

Explore this box plot interactively →