KMO

Across TCGA cell cohorts, KMO mutation is significantly associated with the drug of many other genes, with 12 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible KMO-associated genes across cancer lineages are OF-1, TL-2-105, and Quizartinib. Each is linked with KMO in more than 1 cancer types. Because this analysis shows association rather than direction, both KMO-to-partner and partner-to-KMO results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OF-1 grouped by KMO-low versus KMO-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KMO→partner) and Y-score (partner→KMO) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	OF-1 →	+0.307	+2.646	.034	.047	3	1
LARGE_INTESTINE	TL-2-105 →	+0.423	+2.652	.032	.045	3	1
LARGE_INTESTINE	Quizartinib →	+0.342	+2.652	.034	.045	3	1
LARGE_INTESTINE	CD532 →	+0.417	+2.652	.038	.045	3	1
LARGE_INTESTINE	IWP-2 →	+0.275	+2.893	.039	.034	2	1
LARGE_INTESTINE	GSK2110183B →	+0.655	+2.649	.031	.046	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 12 associations by consensus.

OF-1 by KMO expression — LARGE_INTESTINE

Explore this box plot interactively →