KLRK1-AS1

Across TCGA pan-cancer cohorts, KLRK1-AS1 RNA is linked to patient survival in 22 of 34 cancer types, making it the most broadly survival-associated KLRK1-AS1 data layer.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher KLRK1-AS1 RNA is associated with better overall survival. In most high-consensus cancer types, elevated KLRK1-AS1 expression acts as an unfavorable survival marker, although some lineages such as HNSC and BLCA show a favorable association.

HNSC, BLCA, and COAD are the cancer types where KLRK1-AS1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Tertile	II,III,IV	0.835	0.672	.001	84	view →
BLCA	DFS	Tertile	All	0.649	0.284	<.001	80	view →
COAD	DFS	Quartile	All	0.638	0.402	<.001	75	view →
SKCM	OS	Median	All	0.407	0.266	<.001	60	view →
LUSC	DFS	Median	II,III,IV	0.506	0.295	.001	55	view →
ACC	OS	Quartile	II,III,IV	0.699	0.962	.001	39	view →
THYM	DFS	Median	All	0.634	0.868	.001	38	view →
PCPG	DFS	Median	All	0.918	0.566	.004	27	view →
CESC	OS	Tertile	All	0.895	0.721	.001	26	view →
KIRC	DFS	Tertile	III,IV	0.553	0.696	.012	24	view →
KICH	OS	Median	II,III,IV	0.654	0.958	.008	13	view →
LIHC	OS	Quartile	III,IV	0.903	0.487	.016	10	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 22 lineages.

KLRK1-AS1–HNSC (OS)

Open the HNSC breakdown →