KLRK1-AS1

Across TCGA pan-cancer cohorts, KLRK1-AS1 RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of KLRK1-AS1’s most consistent transcriptional readouts.

The strongest signal is observed in kidney chromophobe (KICH), where KLRK1-AS1 RNA is repressed in tumor relative to normal tissue. In most cancer types KLRK1-AS1 is over-expressed in tumor, although a few such as KICH and BRCA show the opposite, repressed pattern.

KICH, HNSC, and COAD are the cancer types where KLRK1-AS1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in KLRK1-AS1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KICH	All	II,III,IV	−0.747	<.001	9	view →
HNSC	Male	III,IV	+1.219	<.001	8	view →
COAD	Female	II,III,IV	+1.157	<.001	8	view →
BRCA	All	III,IV	−0.786	<.001	8	view →
LUSC	Female	All	+2.892	<.001	7	view →
KIRP	Male	III,IV	+1.298	<.001	6	view →
THCA	All	All	+0.198	.003	6	view →
LUAD	All	All	+0.563	.001	4	view →
BLCA	Female	III,IV	+1.381	.016	3	view →
READ	Female	All	+1.529	.030	2	view →
CHOL	Male	All	+0.570	.010	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 11 strongest of 11 lineages.

KLRK1-AS1–KICH

Open the KICH breakdown →