Across TCGA pan-cancer cohorts, KLRG2 mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated KLRG2 data layer compared with 24 for mass-spec protein and 3 for mutation status.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where higher KLRG2 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated KLRG2 expression acts as an unfavorable survival marker, although some lineages such as LSCC and LUAD show a favorable association.

LSCC, LUAD, and HNSC are the cancer types where KLRG2 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LSCC	DFS	Tertile	All	0.965	0.834	.018	21	view →
LUAD	DFS	Quartile	III,IV	1.000	0.398	.019	6	view →
HNSC	DFS	Median	IV	0.673	0.910	.029	5	view →
CCRCC	OS	Quartile	All	0.380	1.000	.043	3	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

Exploration

Same gene, other analysis: KLRG2 tumor-vs-normal RNA expression · all KLRG2 data types