Across TCGA pan-cancer cohorts, KLRG2 RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of KLRG2’s most consistent transcriptional readouts.
The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where KLRG2 RNA is repressed in tumor relative to normal tissue. In most cancer types KLRG2 is over-expressed in tumor, although a few such as KIRC and KICH show the opposite, repressed pattern.
KIRC, KICH, and COAD are the cancer types where KLRG2 tumor–normal differential expression is most reproducible.
RNA tumor vs normal associations by lineage
Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in KLRG2 RNA (log2); positive values indicate higher expression in tumor. p-values are from the differential-expression test.