KLRG1

Across TCGA patient cohorts, KLRG1 mutation is significantly associated with the RNA expression of many other genes, with 77 significant associations in total. SKCM shows the largest number of these associations.

The most reproducible KLRG1-associated genes across cancer lineages are RN7SL808P, RNA5SP422, and LINC02491. Each is linked with KLRG1 in more than 1 cancer types. Because this analysis shows association rather than direction, both KLRG1-to-partner and partner-to-KLRG1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RN7SL808P grouped by KLRG1-low versus KLRG1-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KLRG1→partner) and Y-score (partner→KLRG1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	RN7SL808P →	+0.163	+6.547	<.001	.001	3	2
UCEC	RNA5SP422 →	+1.521	+3.086	<.001	.007	3	2
LUSC	LINC02491 →	+0.097	+5.742	<.001	.001	3	2
LUSC	MIR4277 →	+0.907	+4.602	<.001	.001	3	2
SCLC	GH2 →	+0.135	+4.624	<.001	.006	3	1
SCLC	TINAG →	+0.081	+4.693	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 77 associations by consensus.

RN7SL808P by KLRG1 expression — COAD

Explore this box plot interactively →