KLRG1

Across TCGA pan-cancer cohorts, KLRG1 RNA is linked to patient survival in 23 of 34 cancer types, making it the most broadly survival-associated KLRG1 data layer compared with 3 for mutation status.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher KLRG1 RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated KLRG1 expression acts as an unfavorable survival marker, although some lineages such as LUAD and HNSC show a favorable association.

LUAD, HNSC, and SKCM are the cancer types where KLRG1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	DFS	Median	All	0.743	0.590	<.001	128	view →
HNSC	DFS	Tertile	All	0.390	0.234	<.001	124	view →
SKCM	OS	Tertile	All	0.401	0.241	<.001	100	view →
LAML	DFS	Tertile	All	0.435	0.714	<.001	36	view →
KIRP	OS	Quartile	III,IV	0.255	1.000	.008	33	view →
UVM	DFS	Quartile	II,III,IV	0.257	0.679	.004	30	view →
CESC	OS	Tertile	II,III,IV	0.910	0.695	.017	26	view →
PAAD	DFS	Tertile	All	0.392	0.263	.007	26	view →
KIRC	DFS	Quartile	All	0.667	0.529	.011	24	view →
LGG	OS	Quartile	All	0.713	0.858	.002	21	view →
SARC	OS	Tertile	All	0.741	0.350	.001	20	view →
OV	DFS	Median	IV	0.402	0.225	.014	16	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 23 lineages.

KLRG1–LUAD (DFS)

Open the LUAD breakdown →