KLRF2

Across TCGA cell cohorts, KLRF2 mutation is significantly associated with the mutation status of many other genes, with 742 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible KLRF2-associated genes across cancer lineages are CBX5, NXPE1, and ARCN1. Each is linked with KLRF2 in more than 1 cancer types. Because this analysis shows association rather than direction, both KLRF2-to-partner and partner-to-KLRF2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CBX5 grouped by KLRF2-low versus KLRF2-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KLRF2→partner) and Y-score (partner→KLRF2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	CBX5 →	+3.672	+4.799	.002	.002	1	1
LARGE_INTESTINE	NXPE1 →	+4.087	+5.044	.001	.001	1	1
LARGE_INTESTINE	ARCN1 →	+3.087	+4.392	.005	.005	1	1
LARGE_INTESTINE	PALMD →	+3.350	+4.584	.003	.003	1	1
LARGE_INTESTINE	FBXL19 →	+4.087	+5.044	.001	.001	1	1
LARGE_INTESTINE	KLHL22 →	+3.087	+4.392	.005	.005	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 742 associations by consensus.

CBX5 by KLRF2 expression — LARGE_INTESTINE

Explore this box plot interactively →