KLRF2

Across TCGA pan-cancer cohorts, KLRF2 RNA is linked to patient survival in 18 of 34 cancer types, making it the most broadly survival-associated KLRF2 data layer.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where higher KLRF2 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated KLRF2 expression acts as an unfavorable survival marker, although some lineages such as SKCM and BRCA show a favorable association.

KIRP, STAD, and SKCM are the cancer types where KLRF2 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRP	DFS	Quartile	II,III,IV	0.494	0.844	<.001	57	view →
STAD	OS	Median	All	0.632	0.806	.013	36	view →
SKCM	DFS	Quartile	All	0.704	0.592	.008	35	view →
BRCA	OS	Median	All	0.976	0.951	.001	34	view →
LUAD	DFS	Median	IV	0.326	0.766	.017	28	view →
CHOL	DFS	Tertile	All	0.124	0.639	.008	24	view →
GBM	OS	Tertile	All	0.322	0.453	.007	15	view →
ACC	OS	Tertile	III,IV	0.276	0.664	.012	9	view →
MESO	DFS	Tertile	All	0.590	0.223	.047	6	view →
LUSC	OS	Median	IV	0.255	0.851	.021	6	view →
LAML	DFS	Quartile	All	0.258	0.459	.025	6	view →
KIRC	DFS	Quartile	All	0.817	0.894	.026	4	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 18 lineages.

KLRF2–KIRP (DFS)

Open the KIRP breakdown →