KLRF1

Across TCGA patient cohorts, KLRF1 mutation is significantly associated with the RNA expression of many other genes, with 1,972 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible KLRF1-associated genes across cancer lineages are PGBD4P2, MIR4774, and TEMN3-AS1. Each is linked with KLRF1 in more than 1 cancer types. Because this analysis shows association rather than direction, both KLRF1-to-partner and partner-to-KLRF1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PGBD4P2 grouped by KLRF1-low versus KLRF1-high in READ.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KLRF1→partner) and Y-score (partner→KLRF1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
READ	PGBD4P2 →	+0.162	+6.257	<.001	.001	3	2
READ	MIR4774 →	+0.841	+6.257	<.001	.001	3	2
UCEC	TEMN3-AS1 →	+0.210	+2.851	<.001	.003	3	2
UCEC	TCP11X3P →	+0.221	+2.409	.003	<.001	3	2
SKCM	KCNIP4-IT1 →	+0.010	+4.603	<.001	.001	3	2
COAD	TRAJ45 →	+1.120	+4.085	<.001	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,972 associations by consensus.

PGBD4P2 by KLRF1 expression — READ

Explore this box plot interactively →