KLRC4-KLRK1

Across TCGA pan-cancer cohorts, KLRC4-KLRK1 Mutation is linked to patient survival in 5 of 34 cancer types, making it a survival-associated KLRC4-KLRK1 data layer compared with 24 for mass-spec protein.

The strongest signal is observed in lung squamous cell carcinoma (LUSC), where higher KLRC4-KLRK1 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated KLRC4-KLRK1 expression acts as an unfavorable survival marker.

LUSC, COAD, and SKCM are the cancer types where KLRC4-KLRK1 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUSC	OS	Median	II,III,IV	0.147	0.743	.002	30	view →
COAD	DFS	Median	II,III,IV	0.510	0.776	<.001	9	view →
SKCM	OS	Median	All	0.245	0.781	.024	9	view →
ACC	DFS	Median	All	0.195	0.748	.003	3	view →
LIHC	DFS	Median	III,IV	0.077	0.414	.004	3	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

KLRC4-KLRK1–LUSC (OS)

Open the LUSC breakdown →