KLRC1

Across TCGA patient cohorts, KLRC1 mutation is significantly associated with the RNA expression of many other genes, with 348 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible KLRC1-associated genes across cancer lineages are RNU6-1055P, MIR328, and BRIX1P1. Each is linked with KLRC1 in more than 2 cancer types. Because this analysis shows association rather than direction, both KLRC1-to-partner and partner-to-KLRC1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-1055P grouped by KLRC1-low versus KLRC1-high in LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KLRC1→partner) and Y-score (partner→KLRC1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUSC	RNU6-1055P →	+0.398	+3.781	.008	.007	3	3
LUAD	MIR328 →	+0.531	+4.043	<.001	.001	3	2
LUAD	BRIX1P1 →	+0.081	+4.636	.005	<.001	3	2
SKCM	EN2 →	+1.151	+3.195	.002	.009	3	2
COAD	LYPLA1P1 →	+0.341	+5.824	<.001	.001	3	2
COAD	MTCO2P32 →	+0.392	+4.807	<.001	.004	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 348 associations by consensus.

RNU6-1055P by KLRC1 expression — LUSC

Explore this box plot interactively →