Q-omics provides the consensus-scored BRIX1P1 profile across patient tissues and cancer cell-line models. BRIX1P1 expression is associated with patient survival in 17 of 34 cancer types, with the highest sampling consensus in BRCA. Among the 18 cancer types available for tumor–normal comparison, BRIX1P1 is differentially expressed in 6, with the highest sampling consensus in STAD. Additionally, BRIX1P1 RNA expression shows 6,931 significant protein co-abundance associations, with the highest sampling consensus in CCRCC. Together, these results highlight BRCA, STAD, and CCRCC as cancer lineages where BRIX1P1 shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for BRIX1P1 — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes BRIX1P1 survival associations across molecular data types. BRIX1P1 RNA expression shows survival associations in the most cancer types (17). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible BRIX1P1 RNA expression–survival associations across cancer types. High BRIX1P1 expression shows unfavorable associations in BRCA, ACC, LUSC, MESO, LGG and LIHC. The BRCA Kaplan–Meier curve shows clear separation, with the high-expression group declining faster, consistent with the unfavorable association (log-rank p < 0.001). Together, the overview and detailed table identify BRCA as the clearest survival context for BRIX1P1 RNA expression.
This table summarizes BRIX1P1 tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 6. The strongest signals are observed in STAD for RNA.
This table ranks reproducible tumor–normal expression differences for BRIX1P1. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. BRIX1P1 shows lower tumor expression in KIRP and higher tumor expression in STAD, LUAD, COAD, BLCA and KICH. The STAD box plot shows higher BRIX1P1 RNA expression in tumor versus normal tissue (log2 FC = +0.103, t-test p = .003).
This table shows molecular features associated with BRIX1P1 in patient tissues and cancer cell lines. In patient samples, BRIX1P1 shows the broadest associations at the RNA and protein expression levels, with CCRCC recurring as the lineage with the largest associated feature set.
