KLK8

Across TCGA patient cohorts, KLK8 mutation is significantly associated with the RNA expression of many other genes, with 2,126 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible KLK8-associated genes across cancer lineages are PPIAL4F, SNORD116-3, and TCF4-AS2. Each is linked with KLK8 in more than 2 cancer types. Because this analysis shows association rather than direction, both KLK8-to-partner and partner-to-KLK8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PPIAL4F grouped by KLK8-low versus KLK8-high in LIHC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KLK8→partner) and Y-score (partner→KLK8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIHC	PPIAL4F →	+0.053	+4.014	<.001	.004	3	3
CESC	SNORD116-3 →	+0.749	+5.103	<.001	.008	3	3
COAD	TCF4-AS2 →	+0.531	+5.392	<.001	.002	3	3
UCEC	PSAT1P4 →	+0.115	+2.094	.006	<.001	3	3
BRCA	SPATA31A5 →	+0.003	+7.471	<.001	.008	3	2
UCEC	CGRRF1 →	+0.341	+2.157	.007	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,126 associations by consensus.

PPIAL4F by KLK8 expression — LIHC

Explore this box plot interactively →