KLK6

Across TCGA patient cohorts, KLK6 mutation is significantly associated with the total protein of many other genes, with 18 significant associations in total. SKCM shows the largest number of these associations.

The most reproducible KLK6-associated genes across cancer lineages are PDK1, PRDX1, and Smad1. Each is linked with KLK6 in more than 1 cancer types. Because this analysis shows association rather than direction, both KLK6-to-partner and partner-to-KLK6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PDK1 grouped by KLK6-low versus KLK6-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KLK6→partner) and Y-score (partner→KLK6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PDK1 →	+0.142	+3.013	.006	.018	3	2
SKCM	PRDX1 →	+0.367	+3.459	.001	.004	3	2
SKCM	Smad1 →	-0.126	-3.000	.028	.034	3	2
SKCM	CDK1 →	+0.202	+1.874	.003	.049	3	2
SKCM	A-Raf_pS299 →	+0.125	+1.749	.029	.049	3	1
SKCM	GAPDH →	+0.503	+2.415	.032	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 18 associations by consensus.

PDK1 by KLK6 expression — UCEC

Explore this box plot interactively →