KLK6

Across TCGA pan-cancer cohorts, KLK6 RNA is linked to patient survival in 20 of 34 cancer types, making it the most broadly survival-associated KLK6 data layer compared with 6 for mutation status and 3 for mass-spec protein.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where higher KLK6 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated KLK6 expression acts as an unfavorable survival marker, although some lineages such as ESCA and THCA show a favorable association.

KIRP, BLCA, and LIHC are the cancer types where KLK6 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRP	OS	Median	All	0.575	0.797	<.001	121	view →
BLCA	DFS	Median	All	0.266	0.407	<.001	82	view →
LIHC	OS	Tertile	All	0.660	0.827	.002	52	view →
ACC	OS	Quartile	All	0.285	0.691	.004	44	view →
ESCA	OS	Median	III,IV	0.671	0.430	.009	39	view →
PAAD	DFS	Tertile	All	0.181	0.422	.002	34	view →
UCEC	DFS	Quartile	All	0.286	0.683	<.001	28	view →
LUSC	OS	Quartile	II,III,IV	0.261	0.792	<.001	18	view →
LUAD	DFS	Median	All	0.739	0.840	.001	18	view →
THCA	DFS	Median	All	0.919	0.663	.007	14	view →
READ	DFS	Median	IV	0.364	0.738	.010	12	view →
SCLC	DFS	Tertile	II,III,IV	0.876	0.406	.022	9	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 20 lineages.

KLK6–KIRP (OS)

Open the KIRP breakdown →