KLK6

Across TCGA cell cohorts, KLK6 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,320 significant associations in total. OVARY shows the largest number of these associations.

The most reproducible KLK6-associated GO terms across cancer lineages are Antimicrobial peptide production, Antimicrobial peptide biosynthetic process, and Antibacterial peptide production. Each is linked with KLK6 in more than 16 cancer types. Because this analysis shows association rather than direction, both KLK6-to-partner and partner-to-KLK6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Antimicrobial peptide production grouped by KLK6-low versus KLK6-high in OVARY.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (KLK6→partner) and Y-score (partner→KLK6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	Antimicrobial peptide production →	+1.637	+4.861	<.001	<.001	3	17
OVARY	Antimicrobial peptide biosynthetic process →	+1.637	+4.861	<.001	<.001	3	17
OVARY	Antibacterial peptide production →	+1.637	+4.861	<.001	<.001	3	17
OVARY	Antibacterial peptide biosynthetic process →	+1.637	+4.861	<.001	<.001	3	17
URINARY_TRACT	Response to indole-3-methanol →	+0.237	+3.568	<.001	<.001	3	10
LUNG_NSCLC_LUAD	Protein localization to cell junction →	+0.129	+2.678	<.001	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,320 associations by consensus.

Antimicrobial peptide production by KLK6 expression — OVARY

Explore this box plot interactively →