KLK6

Across TCGA cell cohorts, KLK6 mutation is significantly associated with the RNA expression of many other genes, with 24 significant associations in total. LUNG_NSCLC_LUAD shows the largest number of these associations.

The most reproducible KLK6-associated genes across cancer lineages are OOSP2, OR10J5, and OR10J1. Each is linked with KLK6 in more than 1 cancer types. Because this analysis shows association rather than direction, both KLK6-to-partner and partner-to-KLK6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OOSP2 grouped by KLK6-low versus KLK6-high in BREAST.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KLK6→partner) and Y-score (partner→KLK6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	OOSP2 →	+0.023	+5.781	<.001	.001	3	1
BREAST	OR10J5 →	+0.071	+5.169	<.001	.005	3	1
BREAST	OR10J1 →	+0.566	+5.781	<.001	.001	3	1
LUNG_NSCLC_LUAD	AGXT2 →	+0.013	+4.786	<.001	<.001	3	1
LUNG_NSCLC_LUAD	DEFB118 →	+0.008	+4.681	<.001	.003	3	1
LUNG_NSCLC_LUAD	GLYAT →	+0.053	+4.169	.006	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 24 associations by consensus.

OOSP2 by KLK6 expression — BREAST

Explore this box plot interactively →