KLK6

Across TCGA cell cohorts, KLK6 mutation is significantly associated with the mutation status of many other genes, with 1,083 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible KLK6-associated genes across cancer lineages are TTC28, ANKRD50, and RSF1. Each is linked with KLK6 in more than 3 cancer types. Because this analysis shows association rather than direction, both KLK6-to-partner and partner-to-KLK6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TTC28 grouped by KLK6-low versus KLK6-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KLK6→partner) and Y-score (partner→KLK6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	TTC28 →	+2.672	+4.225	.008	.008	1	4
OVARY	ANKRD50 →	+4.415	+4.977	.007	.007	1	3
LARGE_INTESTINE	RSF1 →	+2.865	+4.217	.007	.007	1	3
BREAST	ANO3 →	+4.297	+4.857	.009	.009	1	3
BREAST	NFIX →	+5.297	+5.297	.004	.004	1	2
BREAST	SF3B2 →	+4.297	+4.857	.009	.009	1	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,083 associations by consensus.

TTC28 by KLK6 expression — BLOOD_Leukemia

Explore this box plot interactively →