KLK5

Across TCGA patient cohorts, KLK5 mutation is significantly associated with the RNA expression of many other genes, with 1,115 significant associations in total. SKCM shows the largest number of these associations.

The most reproducible KLK5-associated genes across cancer lineages are KRTAP10-13P, IGHD4-17, and H3P46. Each is linked with KLK5 in more than 2 cancer types. Because this analysis shows association rather than direction, both KLK5-to-partner and partner-to-KLK5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, KRTAP10-13P grouped by KLK5-low versus KLK5-high in BLCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KLK5→partner) and Y-score (partner→KLK5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLCA	KRTAP10-13P →	+0.033	+4.444	<.001	.006	3	3
UCEC	IGHD4-17 →	+0.564	+2.492	.001	.008	3	3
UCEC	H3P46 →	+0.087	+3.555	<.001	.002	3	2
BRCA	RN7SKP221 →	+0.099	+8.471	<.001	.005	3	2
SKCM	NCAPH2 →	+0.580	+3.038	<.001	<.001	3	2
UCEC	PITPNM2 →	+0.535	+3.201	.006	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,115 associations by consensus.

KRTAP10-13P by KLK5 expression — BLCA

Explore this box plot interactively →