KLK15

Across TCGA pan-cancer cohorts, KLK15 Mutation is linked to patient survival in 5 of 34 cancer types, making it a survival-associated KLK15 data layer compared with 23 for mass-spec protein.

The strongest signal is observed in colon adenocarcinoma (COAD), where higher KLK15 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated KLK15 expression acts as an unfavorable survival marker.

COAD, PAAD, and LGG are the cancer types where KLK15 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
COAD	OS	Median	All	0.157	0.874	<.001	26	view →
PAAD	OS	Median	All	0.037	0.641	<.001	24	view →
LGG	OS	Median	All	0.187	0.896	<.001	12	view →
BLCA	DFS	Median	III,IV	0.135	0.574	.001	12	view →
UCEC	OS	Median	IV	0.231	0.592	.036	6	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

KLK15–COAD (OS)

Open the COAD breakdown →