KLK14

Across TCGA patient cohorts, KLK14 mutation is significantly associated with the RNA expression of many other genes, with 110 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible KLK14-associated genes across cancer lineages are RNU6-477P, LINC01757, and RN7SL98P. Each is linked with KLK14 in more than 1 cancer types. Because this analysis shows association rather than direction, both KLK14-to-partner and partner-to-KLK14 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-477P grouped by KLK14-low versus KLK14-high in BRCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KLK14→partner) and Y-score (partner→KLK14) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	RNU6-477P →	+0.207	+7.471	<.001	.008	3	2
BRCA	LINC01757 →	+0.134	+6.162	<.001	.002	3	2
BLCA	RN7SL98P →	+0.159	+5.329	<.001	.006	3	2
UCEC	SNRPCP14 →	+0.276	+2.663	.006	.004	3	2
BRCA	RN7SL52P →	+0.153	+6.064	<.001	.002	3	1
UCEC	DDAH1 →	+0.906	+3.202	.007	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 110 associations by consensus.

RNU6-477P by KLK14 expression — BRCA

Explore this box plot interactively →