KLK14

Across TCGA patient cohorts, KLK14 mutation is significantly associated with the total protein of many other genes, with 3 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible KLK14-associated genes across cancer lineages are p62 Lck ligand, MEK1, and Annexin-1. Each is linked with KLK14 in more than 1 cancer types. Because this analysis shows association rather than direction, both KLK14-to-partner and partner-to-KLK14 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, p62 Lck ligand grouped by KLK14-low versus KLK14-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KLK14→partner) and Y-score (partner→KLK14) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	p62 Lck ligand →	+0.464	+2.817	.013	.036	2	1
UCEC	MEK1 →	+0.469	+3.000	.026	.037	1	1
UCEC	Annexin-1 →	+0.907	+3.000	.002	.037	1	1

Each partner links to its Q-omics profile. Showing the 3 strongest of 3 associations by consensus.

p62 Lck ligand by KLK14 expression — UCEC

Explore this box plot interactively →