KLK14

Across TCGA cell cohorts, KLK14 RNA expression is significantly associated with the go_rna of many other GO terms, with 2,817 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible KLK14-associated GO terms across cancer lineages are Viral transcription, Negative regulation of translational initiation, and Regulation of mRNA splicing, via spliceosome. Each is linked with KLK14 in more than 10 cancer types. Because this analysis shows association rather than direction, both KLK14-to-partner and partner-to-KLK14 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Viral transcription grouped by KLK14-low versus KLK14-high in LUNG_SCLC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (KLK14→partner) and Y-score (partner→KLK14) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	Viral transcription →	+0.106	+0.851	.001	.003	3	11
LARGE_INTESTINE	Negative regulation of translational initiation →	+0.097	+0.824	<.001	.001	3	11
BONE	Regulation of mRNA splicing, via spliceosome →	+0.052	+0.232	.008	.007	3	11
BLOOD_Lymphoma	Establishment of RNA localization →	+0.069	+0.294	.002	.005	2	11
BLOOD_Leukemia	RNA export from nucleus →	+0.083	+0.318	<.001	<.001	3	10
STOMACH	Post-transcriptional gene silencing →	+0.140	+0.945	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,817 associations by consensus.

Viral transcription by KLK14 expression — LUNG_SCLC

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