KLK11

Across TCGA patient cohorts, KLK11 mutation is significantly associated with the total protein of many other genes, with 12 significant associations in total. SKCM shows the largest number of these associations.

The most reproducible KLK11-associated genes across cancer lineages are Cyclin-B1, MEK1, and ACC_pS79. Each is linked with KLK11 in more than 1 cancer types. Because this analysis shows association rather than direction, both KLK11-to-partner and partner-to-KLK11 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Cyclin-B1 grouped by KLK11-low versus KLK11-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KLK11→partner) and Y-score (partner→KLK11) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	Cyclin-B1 →	+0.556	+3.700	.003	.001	3	2
UCEC	MEK1 →	+0.370	+2.321	.025	.034	3	2
SKCM	ACC_pS79 →	+0.276	+2.584	.040	.011	3	1
SKCM	FOXO3a →	-0.120	-3.169	.024	.017	3	1
SKCM	PKC-a_pS657 →	-0.422	-3.000	.018	.034	3	1
SKCM	Rb_pS807_S811 →	+0.670	+3.321	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 12 associations by consensus.

Cyclin-B1 by KLK11 expression — SKCM

Explore this box plot interactively →