KLK11

Across TCGA pan-cancer cohorts, KLK11 RNA differs between tumor and matched normal tissue in 10 of 18 cancer types tested, making tumor–normal expression one of KLK11’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where KLK11 RNA is repressed in tumor relative to normal tissue. In most cancer types KLK11 is over-expressed in tumor, although a few such as HNSC and LUAD show the opposite, repressed pattern.

HNSC, THCA, and COAD are the cancer types where KLK11 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in KLK11 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Male	II,III,IV	−1.906	<.001	11	view →
THCA	Male	All	+3.169	<.001	10	view →
COAD	Male	II,III,IV	+2.224	<.001	10	view →
LUAD	Female	III,IV	−3.946	<.001	9	view →
BRCA	All	III,IV	−1.800	<.001	6	view →
KIRC	Male	II,III,IV	−0.196	<.001	6	view →
LUSC	Female	II,III,IV	−3.745	<.001	5	view →
LIHC	Male	All	−0.346	<.001	2	view →
CHOL	All	All	+2.562	.009	1	view →
ESCA	All	All	−2.256	.019	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 10 strongest of 10 lineages.

KLK11–HNSC

Open the HNSC breakdown →