KLK11

Across TCGA cell cohorts, KLK11 mutation is significantly associated with the RNA expression of many other genes, with 4 significant associations in total. OVARY shows the largest number of these associations.

The most reproducible KLK11-associated genes across cancer lineages are IL22, LRRC72, and MS4A10. Each is linked with KLK11 in more than 1 cancer types. Because this analysis shows association rather than direction, both KLK11-to-partner and partner-to-KLK11 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, IL22 grouped by KLK11-low versus KLK11-high in STOMACH.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KLK11→partner) and Y-score (partner→KLK11) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	IL22 →	+0.046	+5.285	<.001	.003	3	1
STOMACH	LRRC72 →	+0.093	+5.285	<.001	.003	3	1
OVARY	MS4A10 →	+0.013	+5.196	<.001	.005	3	1
OVARY	CBLL2 →	+0.025	+5.196	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 4 strongest of 4 associations by consensus.

IL22 by KLK11 expression — STOMACH

Explore this box plot interactively →