KLK1

Across TCGA patient cohorts, KLK1 protein abundance is significantly associated with the RNA expression of many other genes, with 991 significant associations in total. PDAC shows the largest number of these associations.

The most reproducible KLK1-associated genes across cancer lineages are MT1G, R3HDML, and DNAJC5. Each is linked with KLK1 in more than 1 cancer types. Because this analysis shows association rather than direction, both KLK1-to-partner and partner-to-KLK1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, KLK1 versus MT1G in PDAC, with a Pearson correlation of 0.34.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KLK1→partner) and Y-score (partner→KLK1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	MT1G →	+1.491	+0.905	.001	.004	3	2
COAD	R3HDML →	-0.911	-0.522	.007	.002	3	1
COAD	DNAJC5 →	-0.464	-0.554	.002	.003	3	1
COAD	MRGBP →	-0.428	-0.480	.002	.003	3	1
COAD	GID8 →	-0.527	-0.546	<.001	.003	3	1
COAD	POFUT1 →	-0.496	-0.392	.005	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 991 associations by consensus.

KLK1 vs MT1G — PDAC

Explore this scatter interactively →