KLK1

protein abundance — cross-omics
Cross-omicsPROTEIN-MS → PROTEIN-MSPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, KLK1 protein abundance is significantly associated with the protein abundance of many other proteins, with 4,091 significant associations in total. PDAC shows the largest number of these associations.

The most reproducible KLK1-associated proteins across cancer lineages are CA4, CLK3_S157, and CXXC1_S224. Each is linked with KLK1 in more than 1 cancer types. Because this analysis shows association rather than direction, both KLK1-to-partner and partner-to-KLK1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, KLK1 versus CA4 in PDAC, with a Pearson correlation of 0.39.

protein abundance associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (KLK1→partner) and Y-score (partner→KLK1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.
LineagePartner proteinX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
PDACCA4 →+0.813+0.742<.001<.00132
PDACCLK3_S157 →-0.651-0.762<.001<.00132
COADCXXC1_S224 →+0.484+0.707.004.00132
COADSEC16A_S1069 →+0.301+0.592.001<.00132
PDACSLC4A4 →+0.513+0.692<.001<.00132
PDACSLC4A4_S1025 →+0.624+0.692<.001<.00132
Each partner links to its Q-omics profile. Showing the 6 strongest of 4,091 associations by consensus.

KLK1 vs CA4 — PDAC

Per-sample scatter of KLK1 vs CA4 in PDAC (Pearson r = 0.39).

Explore this scatter interactively →

Exploration