KLK1

Across TCGA patient cohorts, KLK1 mutation is significantly associated with the RNA expression of many other genes, with 3,464 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible KLK1-associated genes across cancer lineages are TUBBP11, RNU6-1089P, and MIR6795. Each is linked with KLK1 in more than 1 cancer types. Because this analysis shows association rather than direction, both KLK1-to-partner and partner-to-KLK1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TUBBP11 grouped by KLK1-low versus KLK1-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KLK1→partner) and Y-score (partner→KLK1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	TUBBP11 →	+0.117	+3.564	.004	.005	3	2
SKCM	RNU6-1089P →	+0.303	+4.356	<.001	.001	3	2
HNSC	MIR6795 →	+0.438	+7.954	<.001	.008	3	2
UCEC	USP9YP2 →	+0.014	+4.744	<.001	.001	3	2
UCEC	RNA5SP164 →	+0.082	+3.738	<.001	.009	3	2
BRCA	RNU6-290P →	+0.357	+7.731	<.001	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,464 associations by consensus.

TUBBP11 by KLK1 expression — SKCM

Explore this box plot interactively →