KLK1

Across TCGA patient cohorts, KLK1 mutation is significantly associated with the total protein of many other genes, with 17 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible KLK1-associated genes across cancer lineages are eIF4E, JNK2, and Ku80. Each is linked with KLK1 in more than 2 cancer types. Because this analysis shows association rather than direction, both KLK1-to-partner and partner-to-KLK1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eIF4E grouped by KLK1-low versus KLK1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KLK1→partner) and Y-score (partner→KLK1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eIF4E →	+0.174	+2.321	.046	.006	3	1
UCEC	JNK2 →	+0.252	+2.321	.002	.006	3	1
UCEC	Ku80 →	+0.217	+1.820	.025	.016	3	1
UCEC	MEK1 →	+0.442	+3.906	.003	<.001	3	1
UCEC	p62 Lck ligand →	+0.273	+1.807	.042	.027	3	1
UCEC	P-Cadherin →	-0.131	-2.308	.027	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 17 associations by consensus.

eIF4E by KLK1 expression — UCEC

Explore this box plot interactively →