KLK1

Across TCGA cell cohorts, KLK1 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,349 significant associations in total. BONE shows the largest number of these associations.

The most reproducible KLK1-associated GO terms across cancer lineages are Negative regulation of actin nucleation, Response to steroid hormone, and Regulation of tolerance induction dependent upon immune response. Each is linked with KLK1 in more than 6 cancer types. Because this analysis shows association rather than direction, both KLK1-to-partner and partner-to-KLK1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of actin nucleation grouped by KLK1-low versus KLK1-high in LUNG_SCLC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (KLK1→partner) and Y-score (partner→KLK1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	Negative regulation of actin nucleation →	+0.212	+1.086	<.001	.007	3	7
PANCREAS	Response to steroid hormone →	+0.087	+1.208	<.001	<.001	3	6
STOMACH	Regulation of tolerance induction dependent upon immune response →	+1.008	+1.976	.005	.002	2	7
BONE	Cytotoxic T cell degranulation →	+0.220	+0.805	<.001	<.001	3	6
LARGE_INTESTINE	Epithelial tube branching involved in lung morphogenesis →	+0.145	+1.518	.003	.003	3	6
LUNG_SCLC	Cellular response to ketone →	+0.075	+1.267	.003	.007	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,349 associations by consensus.

Negative regulation of actin nucleation by KLK1 expression — LUNG_SCLC

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