KLK1

Across TCGA cell cohorts, KLK1 mutation is significantly associated with the RNA expression of many other genes, with 6 significant associations in total. LUNG_NSCLC_LUAD shows the largest number of these associations.

The most reproducible KLK1-associated genes across cancer lineages are CHRNB3, GYPB, and OR51F2. Each is linked with KLK1 in more than 1 cancer types. Because this analysis shows association rather than direction, both KLK1-to-partner and partner-to-KLK1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CHRNB3 grouped by KLK1-low versus KLK1-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KLK1→partner) and Y-score (partner→KLK1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	CHRNB3 →	+0.011	+4.467	<.001	.004	3	1
SKIN	GYPB →	+0.120	+4.467	.001	.004	3	1
LUNG_NSCLC_LUAD	OR51F2 →	+0.022	+5.662	<.001	.002	3	1
LUNG_NSCLC_LUAD	C1orf185 →	+0.053	+4.887	<.001	.009	3	1
LUNG_NSCLC_LUAD	PMIS2 →	+0.038	+5.228	<.001	.005	3	1
SKIN	ETV3L →	+0.022	+4.199	.001	.007	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 6 associations by consensus.

CHRNB3 by KLK1 expression — SKIN

Explore this box plot interactively →